Researcher Develops Innovative Tool for Early Cancer Diagnosis

A researcher from the South Island of New Zealand is on the verge of developing a groundbreaking tool aimed at diagnosing early-stage cancers more accurately. Dr. Judy Ann Cocadiz of the University of Otago has been awarded a three-year, $300,000 post-doctoral fellowship from the Cancer Society in their 2025 National Research Grant Round. Her work focuses on a novel method for capturing circulating tumour DNA (ctDNA) from patients, which could significantly enhance early cancer detection and monitoring.

Dr. Cocadiz’s research centers on ctDNA, which consists of DNA fragments released by cancer cells into the bloodstream. The presence of ctDNA correlates with the severity of cancer; as the disease progresses, the concentration of ctDNA increases. Currently, doctors detect ctDNA through blood samples, typically requiring between 8-10 milliliters of blood. Dr. Cocadiz noted the limitations of this method, especially for early-stage cancers. “In early-stage cancer, there is not a lot of ctDNA in 10ml of blood. It is like looking for a needle in a haystack,” she explained.

To address this challenge, Dr. Cocadiz is developing a small device that can be inserted into a blood vessel, acting as a “sieve” to capture ctDNA over a short period. This approach aims to minimize discomfort for patients while allowing for more effective detection of cancers, even at early stages. “We wanted to create a device that collects ctDNA without needing to draw more blood, which can be particularly challenging for children or frail individuals,” she added.

The device is still in the proof of concept phase but is designed to function similarly to an intravenous (IV) line. It would be inserted into a patient’s blood vessel like a needle, allowing for a brief collection of ctDNA before being removed. Although clinical use of this device is years away, Dr. Cocadiz remains optimistic about the potential impact of her work. “I am really grateful for this grant from the Cancer Society. They are not just funding this research; they are supporting the early stages of my career as well,” she remarked.

Dr. Cocadiz’s path to cancer research was inspired by a childhood experience in the Philippines. At just five years old, she noticed that her best friend often had large bruises from minor injuries. Concerned, she informed her parents, who subsequently took her friend to the doctor. He was diagnosed with early-stage leukaemia and received prompt treatment. Reuniting with him earlier this year, Dr. Cocadiz was pleased to see him healthy and thriving.

Although she initially considered a career as a doctor, Dr. Cocadiz decided to focus on cancer research instead. Reflecting on her journey, she said, “Everything just kind of fell into place, and I am really glad I ended up in cancer research.” With support from the Cancer Society and her own determination, Dr. Cocadiz is poised to make significant contributions to the field of oncology in the years to come.