Researcher Develops Innovative Tool for Early Cancer Detection

A childhood friend’s battle with cancer has inspired a South Island researcher to pursue groundbreaking work in cancer diagnostics. Dr. Judy Ann Cocadiz, based at the University of Otago, has been awarded a three-year, $300,000 post-doctoral fellowship from the Cancer Society. This funding will support her research into a new diagnostic tool aimed at improving the accuracy of early-stage cancer detection.

Dr. Cocadiz’s work focuses on circulating tumour DNA (ctDNA), which are DNA fragments released into the bloodstream by cancer cells. The concentration of ctDNA typically increases as cancer progresses, making it a valuable biomarker for diagnosis and monitoring. Currently, testing for ctDNA involves drawing blood samples, which can be problematic in early-stage cancers due to the low concentration of ctDNA present.

In her innovative approach, Dr. Cocadiz is developing a small device designed to be inserted into a blood vessel. This device would act as a “sieve,” capturing ctDNA over a brief period. Such a method could significantly enhance the detection of cancers at their earliest stages and help monitor for residual or recurring cancer post-treatment.

“This device would allow us to collect ctDNA without requiring large blood volumes,” Dr. Cocadiz explained. “Typically, only 8-10 ml of blood is drawn, which is insufficient in early-stage cases. It’s like searching for a needle in a haystack.” By minimizing the discomfort and risk associated with drawing more blood, especially in vulnerable patients such as children or the elderly, her device aims to revolutionize cancer diagnostics.

While Dr. Cocadiz’s research is still in the proof-of-concept phase, she envisions that the device could be used similarly to an intravenous (IV) line. It would be inserted into a patient’s blood vessel with ease and then removed after collecting the necessary ctDNA.

Although there are years of development ahead before clinical implementation, Dr. Cocadiz remains optimistic. “I am incredibly grateful for this grant from the Cancer Society, which not only funds my research but supports the early stages of my career,” she stated.

Her interest in cancer research was ignited during her childhood in the Philippines. At just five years old, Dr. Cocadiz noticed her best friend frequently had large bruises from minor accidents. Concerned, she encouraged her parents to seek medical advice, leading to a diagnosis of early-stage leukaemia. Thanks to swift medical intervention, her friend received immediate treatment and is now doing well.

Reflecting on her journey, Dr. Cocadiz acknowledged that while she initially considered becoming a doctor, she found her true calling in cancer research. “Everything just kind of fell into place, and I am really glad I ended up in cancer research,” she said, emphasizing her commitment to improving outcomes for cancer patients.

As she embarks on this pivotal research journey, Dr. Cocadiz’s work holds the promise of not only advancing scientific knowledge but also making a tangible difference in the lives of those affected by cancer.