South Island Researcher’s Cancer Tool Inspired by Childhood Friend

A childhood friend’s battle with cancer has ignited a significant career for South Island researcher Dr. Judy Ann Cocadiz. Her innovative work aims to improve the accuracy of early-stage cancer diagnoses. Dr. Cocadiz, affiliated with the University of Otago, has been awarded a $300,000 post-doctoral fellowship as part of the Cancer Society’s 2025 National Research Grant Round.

Dr. Cocadiz’s research focuses on circulating tumour DNA (ctDNA), which are fragments of DNA released by cancer cells into the bloodstream. The concentration of ctDNA typically increases as cancer progresses, making it a valuable biomarker for diagnosis and monitoring. She is developing a device that can be inserted into a blood vessel, acting as a “sieve” to capture ctDNA for analysis. This advancement could revolutionize the way doctors detect cancers at earlier stages and monitor patients for residual or recurring disease after treatment.

Current methods involve drawing blood samples, usually around 8-10 ml, but this poses challenges in early-stage cancer where ctDNA levels are low. Dr. Cocadiz explained, “It is like looking for a needle in a haystack.” She noted the ethical implications of extracting larger blood samples, particularly for vulnerable populations such as children and frail individuals.

The device she envisions would function similarly to an intravenous (IV) line, allowing for a brief collection of ctDNA before being safely removed. This approach not only minimizes discomfort for patients but also enhances the chances of early and accurate cancer detection. While her research remains in the proof-of-concept phase, Dr. Cocadiz remains optimistic about its potential. “I am really grateful for this grant from the Cancer Society,” she stated, emphasizing its importance in supporting her research and early career.

Dr. Cocadiz’s commitment to cancer research is deeply personal. Her interest in the field was sparked in her preschool years in the Philippines when she noticed her best friend frequently had unexplained bruises. Concerned, she informed her parents, which led to a medical evaluation. Her friend was diagnosed with early-stage leukaemia, enabling timely treatment. Reuniting with him earlier this year, Dr. Cocadiz was delighted to see that he has fully recovered.

After completing her PhD in biochemistry last year, Dr. Cocadiz redirected her career aspirations away from becoming a doctor, choosing instead to focus on cancer research. “Everything just kind of fell into place,” she reflected, expressing her satisfaction with her path in the fight against cancer.

The next steps in bringing Dr. Cocadiz’s device to clinical use will take time, but the implications of her research could be profound. By improving the methods of detecting and monitoring cancer, her work has the potential to make significant strides in cancer care and patient outcomes. As she continues her research, the support from organizations like the Cancer Society is crucial, not only for funding but for fostering innovation in the essential field of oncology.